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Sublingual (under the tongue) administration is a delivery method whereby substances are absorbed directly into the blood vessels and lymphatics of the mouth. Drugs absorbed through the small intestine (those ingested) are carried immediately to the liver, where a high percentage of them are often destroyed. This immediate destruction of active agents by gastric acid and the liver is known as the “first pass effect.” The area under the tongue is highly vascularized and rapidly absorbs a wide variety of substances. Sublingual delivery therefore results in faster therapeutic action, and the delivery of more therapeutic agent as there is no destruction by the first pass effect.
The Oradose dispenser is a unique delivery system developed by GelStat that incorporates technology used to improve absorption of GelStat™ Migraine. The OraDose™ delivery system is an important part of GelStat’s effort to create products that work faster, are more effective and offer better safety profiles than similar products administered by traditional means. Medications absorbed through the digestive tract generally take over an hour to reach peak plasma concentration, and absorption is highly variable. With the OraDose™ delivery system, GelStat™ Migraine achieves consistent absorption that begins within seconds, for relief that is often noticeable within minutes.
Sublingual drug administration has been found clinically useful for cardiovascular drugs, steroids, and some barbiturates and enzymes. However, its use in the OTC arena has been almost entirely neglected.
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